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JDRF has now rebranded to Breakthrough T1D.
Our name has changed, our mission has not.

Take part in type 1 diabetes clinical trials

Learn more about what clinical trials are and why they are so important for research. See below for clinical trials currently available for recruitment through Breakthrough T1D, or use the type 1 diabetes clinical trial finder tool, to find trials that are currently recruiting people like you.
Content last reviewed and updated: 13.05.2025

What are clinical trials?

Clinical trials are research studies that test any kind of treatment in people to find out if they are safe and effective. There are three stages of clinical trials, each involving more participants. They are a crucial step in the research pipeline that can only happen once a treatment has been thoroughly tested in cells and animals in the lab, which are known as preclinical trials.

You can learn more about clinical trials on the government’s clinical trials website.

Why take part in research?

Volunteering to be part of research is a tremendous help to type 1 diabetes researchers. Without volunteers taking part in these studies, it would not be possible to develop any new therapies for type 1.

T1D-Plus

People aged 18-44 years old living with type 1 diabetes, who have started insulin in the last 6 weeks

If you have recently been diagnosed with type 1 diabetes, you could help researchers test several different treatments and their ability to preserve beta cell function.

  • Looking for individuals (18-44 years old) living with type 1 diabetes who have started insulin in the last 6 weeks.
  • To take part in the trial by attending 3-monthly visits over 12 months for a mixed meal tolerance test (MMTT) to measure beta cell function: involves drinking a liquid meal and measuring insulin levels for 2 hours.

To learn more, see the current trial sites available, and get involved please visit the T1D Plus website.

Please be aware that more sites will become available, so please check back in each month.

SOPHIST-trial

Individuals living with T1D and heart failure symptoms

If you live with type 1 diabetes and heart failure symptoms, you could help researchers understand if a tablet, called sotagliflozin, could improve the quality of live in people with type 1 diabetes and heart failure.

  • Looking for individuals living with type 1 diabetes and a diagnosis of heart failure or symptoms that could be related to diabetes-related heart changes such as breathlessness, ankle swelling or fatigue.
  • Take part in the trial by being assigned to one or two groups (sotagliflozin or placebo) for approximately 6 months, involving 5 in-person hospital visits and 3 telephone or video calls with the research team. With clinical trial sites across the UK.

To learn more, see the current trial sites available, and express your interest in taking part in the trial, please fill out our Expression of Interest form.

Please be aware that more study sites will become available, so please check back in each month.

What if I can’t find a clinical trial to join?

If you can’t find anything suitable from the above opportunity(ies) or the clinical trial finder below, you could ask your doctor if they know of any studies which might be appropriate for you. You can also have a look at the National Institute of Health Research (NIHR) Be a part of Research website to search for current type 1 diabetes clinical trials.

The type 1 diabetes clinical trial finder

Clicking the tool below will take you to the Antidote website, a digital health company who created and support this tool. You will be asked several questions about you and your health to search which clinical trials you may be able to take part in.

Shared stories

Platforms running clinical trials

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UK T1D Research Consortium logo

UK T1D Research Consortium

The UK T1D Research Consortium is funded by Breakthrough T1D UK and Diabetes UK. It is a platform recruiting volunteers to join clinical trials of new immunotherapies for type 1.

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INNODIA

INNODIA is a platform that recruits Europeans under 45 who were either diagnosed with type 1 in the last six weeks or have a close relative with type 1. They do blood tests to show who is likely to later develop type 1 and invite them to take part in clinical trials of possible treatments.

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ADDRESS-2 logo

ADDRESS-2

ADDRESS-2 supports research involving people with type 1 diabetes who want to take part, from the moment they are diagnosed. They help connect people diagnosed in the last six months with researchers running clinical trials.