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Home > News & events > News > JDRF and Medical Research Council co-fund new research into type 1 diabetes treatments
The award funds registered healthcare professionals to complete a PhD. The scheme is available for projects focusing on many different conditions, making it incredibly competitive. A type 1 healthcare professional receiving this fellowship will help raise the profile of type 1 diabetes research and JDRF amongst researchers, healthcare professionals and government funders. We hope this will attract new funding and researchers to the field of type 1 diabetes research.
Thanks to this funding, Daniel Doherty will complete his PhD at the University of Manchester over the next three years. His project will focus on improving the outcome of islet transplants for people with type 1. His goal is for islet transplants to work better, for longer, so they can help more people with type 1.
Islets are clusters of cells in the pancreas, which contain the insulin-producing beta cells that are destroyed in type 1 diabetes.
Daniel Doherty said: “An islet transplant takes the insulin-producing cells from an organ donor’s pancreas and places them into a recipient experiencing severe type 1 diabetes. It has the potential to free patients from taking insulin.”
Islet transplants can help people with type 1 who struggle with their glucose control, but they are far from perfect. Daniel Doherty said: “At the moment islet transplantation is only available for a small group of patients as the transplants gradually decline in function and recipients need two or three transplants, limiting the total number of recipients that can benefit from the procedure.
“I am investigating how the locations that transplants are placed into interact with the insulin producing cells to see how we can make them survive longer, control blood sugar better and make it available for more people with type 1.”
Daniel will start his PhD by learning more about islets and their neighbouring cells. Islets are usually found in the pancreas, but they are transplanted into the liver because it is much easier to get to than the pancreas. Daniel will investigate why many islets don’t survive in the liver and how he could improve this.
To do this, Daniel will look closely at islets in pancreas samples donated by people without type 1. He will also figure out what types of cells are present after the islets have been separated from the rest of the pancreas. Finally, he will compare both findings with the cells that surround the islets when they reach the liver. This will help him understand how the islets interact with neighbouring cells to help them function.
Daniel hopes to use this information to create a more supportive environment for islet cells in the liver. Through this, he aims to get more islets to survive the transplant so that the people with type 1 who receive them can produce insulin more effectively.
This research will help limit the number of repeat islet transplants required, making them available for more people with type 1.
To explain his research in more detail, Daniel created this short video, which you can watch below.
A recent study has shown that a treatment currently used for type 2 diabetes could be used to help prevent kidney damage in young adults with type 1
We’re aware of growing concern around insulin supply in the UK, and we want to reassure our community that this is not a general insulin shortage. There is no need to change the type of insulin you use.
New data from Sana Biotechnology, in collaboration with Uppsala University Hospital in Sweden, shows that six months post-transplant, one person with type 1 diabetes (T1D) is successfully producing insulin and does not require immunosuppression.
US-based company Vertex have published promising figures from their cell therapy trial, showing advancements in stem cell research.
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