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JDRF has now rebranded to Breakthrough T1D.
Our name has changed, our mission has not.

Our research

One day, we will create a world without type 1 diabetes. Until that day, your support is vital for our international research to cure, treat and prevent type 1.

A type 1 diabetes researcher working on a beta cells project, in the lab.

What research does Breakthrough T1D UK fund?

We fund international research that will cure, treat and prevent type 1 diabetes and its complications. We focus on investing in research that will transform the lives of people with type 1 diabetes – improving treatments today until we find a cure.

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400+

Over 400 active research studies are being funded by Breakthrough T1D UK around the world

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21

Breakthrough T1D UK-funded research is currently taking place in 21 countries

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20

At any one time, Breakthrough T1D UK is funding around 20 research projects in the UK

Learn about our research

Discover how we’re working to cure, treat and prevent type 1 diabetes

Recent research highlights

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A girl with type 1 diabetes after a teplizumab injection
Treatments

Teplizumab: The world’s first type 1 diabetes disease-modifying drug approved in the US

The US FDA recently approved a drug that can delay the onset of type 1 diabetes for up to three years, called teplizumab. This success wouldn’t have happened without 30 years of Breakthrough T1D UK funding research.

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Illustration of the hybrid closed loop technology system, funded as part of treatment research for type 1 diabetes by Breakthrough T1D UK.
Treatments

Hybrid closed loop to be recommended for over 100,000 people with type 1 diabetes

Since 2006, we have funded research to develop and test hybrid closed loop (HCL) technology, which links people's insulin pump to their continuous glucose monitor. Now, HCL is set to become available to many people on the NHS.

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Microscopic view of stem cells
Cure

Promising stem cell therapy for type 1 given green light to progress

For over 20 years, we funded Professor Doug Melton to grow stem cells into insulin-producing beta cells. Doug now works at Vertex Pharmaceuticals, who are running a clinical trial transplanting Doug’s lab-grown beta cells into people with type 1.

Latest research projects

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A photo of researcher Dr Tom Wylie, a pale person with a beard and glasses
Prevention

How can we better understand mental health risks in people with type 1 diabetes?

Dr Tom Wylie’s pioneering research project investigating the psychological impact of type 1 diabetes (T1D), in partnership with the Daphne Jackson Trust. The study, entitled Retrospective Longitudinal Analysis of Diabetes' psychological impact to stratify risk (RELOAD), will explore whether it is possible to identify people who may need mental health support following a T1D diagnosis.

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A photo of Professor Kathleen Gillespie, a researcher investigating pancreatic function in type 1 diabetes.
Prevention

What causes immune cells to attack beta cells in the pancreas?

Dr Kathleen Gillespie and her team are researching how signalling molecules help coordinate immune cell attacks on the pancreas, contributing to T1D development.

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A photo of Professor Kathleen Gillespie, a researcher investigating pancreatic function in type 1 diabetes.
Prevention

What can pancreatic function tell us about how quickly type 1 diabetes develops?

Dr Kathleen Gillespie and her team will investigate whether existing tests could help predict how quickly a person in the early stages of T1D will progress.

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A photo of Dr Matthew Anson, a researcher funded by Breakthrough T1D and Novo Nordisk UK Research Foundation.
Treatment

Can hybrid closed loop technology affect eye problems in type 1 diabetes?

Dr Matthew Anson is studying whether hybrid closed loop technology, also known as an artificial pancreas, affects the worsening of diabetic eye disease.

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A photo of researcher Dr Samet Sahin in his science lab.
Treatment

Engineering a device to measure how much insulin someone is making

Dr Samet Sahin is developing a simple tool to allow healthcare professionals to quickly and easily check someone’s C-peptide levels, a measure of how much insulin they are releasing.

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Treatment

Studying cells in the pancreas to help prevent low blood glucose in type 1 diabetes

Dr Thomas George Hill is studying a type of pancreatic islet cell, called a delta cell, which he thinks could be targeted with a treatment to help prevent low blood glucose in type 1 diabetes.

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A photo of Dr Rebecca Dewhurst-Trigg smiling and wearing a black top.
Prevention

Could islet helper cells in the pancreas delay or prevent type 1 diabetes?

Dr Rebecca Dewhurst-Trigg is investigating how supportive cells called mesenchymal stromal cells may help protect insulin-making beta cells from being destroyed in type 1 diabetes.

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A photo of Dr Richard Pulsford.
Treatment

Developing a simple tool to help people with type 1 diabetes exercise

Dr Richard Pulsford is developing a visual tool for people with type 1 diabetes that predicts the likelihood of their blood glucose going too low during exercise

Stories from the lab

Latest research news

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Female doctor with smiling patient in clinic setting
Research
26 March 2025

Making medical research programmes and clinical trials more accessible and inclusive

Read our top takeaways from the ‘Recruiting to medical research programmes and trials – how can we be smarter and more equitable?’ webinar.

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Young man and woman with type 1 diabetes using diabetes technology
News
25 March 2025

Novo Nordisk to discontinue Levemir insulin by end of 2026

Novo Nordisk will stop producing Levemir insulin next year but there are plans in place to help you transition to an alternative.

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Islet cells from human donors
Research
17 March 2025

Breakthrough in T1D treatment: Improving islet transplantation

Researchers funded by Breakthrough T1D in the US have published promising new data that could help to improve islet transplantation for people with T1D.

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A researcher looking through a microscope at a kidney on a chip.
News
4 March 2025

UK diabetes and kidney charities establish key research and healthcare recommendations for diabetic kidney disease

A new paper co-authored by Breakthrough T1D, Diabetes UK, and Kidney Research UK has identified six themes to tackle diabetic kidney disease.

Our research partnerships

We work with researchers and partner organisations to make sure we can improve life with type 1 diabetes as quickly as possible. Learn about the research we do in partnership with other organisations.

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Our research partnerships

Discover how we work with other organisations to help us make every penny we receive from our amazing supporters go even further to help people with type 1.

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Connect Immune Research

Learn about how we're partnering with other autoimmune research funders, pooling our resources to help prevent and cure a range of autoimmune conditions, including type 1 diabetes.

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A woman type 1 diabetes scientist in a laboratory

The Type 1 Diabetes Grand Challenge

The Type 1 Diabetes Grand Challenge is a partnership between the Steve Morgan Foundation, Diabetes UK and Breakthrough T1D UK. We are united by our ambition to cure type 1 diabetes.